Significance of endothelin-1 differential expression in sera and CSF of patients with acute craniocerebral inju-ry
10.3760/cma.j.issn.1008-6706.2014.07.004
- VernacularTitle:急性颅脑损伤患者脑脊液和血清内皮素的表达及意义
- Author:
Na LI
;
Jincheng CHEN
;
Yilong QI
;
Wenjuan ZHANG
;
Lindi SUN
;
Xian'an SHAO
;
- Publication Type:Journal Article
- Keywords:
Craniocerebral trauma;
Endothelin-1;
Cerebospinal fluid;
Serum
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(7):968-969
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate clinical significance of the varied concentration of cytokines in patients , the concentration of endothelin-1(ET-1) in cerebrospinal fluid(CSF) and serum were investigated in 36 patients with acute craniocerebral injury .Methods In this study ,36 patients with acute craniocerebral injury were divided into two groups by their GCS scores ( GCS≤12 as moderate-severe injury group ,GCS>12 as mild injury group ) .Concentration of ET-1 in CSF and serum in 36 patients with acute craniocerebral injury were detected by ELISA .Results The con-centration of ET-1 was(38.89 ±9.50)μg/L in cerebrospinal fluid ( CSF) in moderate to severe patients ,which were significantly higher than that in mild injury groups [(22.25 ±8.55)μg/L](t=5.453,P=0.000) and control groups [(15.67 ±7.72)μg/L](t=8.347,P=0.000).And the levels of ET-1 in CSF in the mild injury groups were also obviously higher than that of the control groups (t=2.390,P=0.023).On the other hand,the concentration of ET-1 was(107.02 ±17.25)μg/L in sera in moderate to severe patients ,which were also significantly higher than that in mild injury groups[(46.21 ±11.19)μg/L](t=12.176,P=0.000)and control groups[(32.34 ±10.64)μg/L] (t=16.163,P=0.000).And the levels of ET-1 in sera in the mild injury groups were obviously higher than that of the control groups(t=3.751,P=0.001).The concentration of ET-1 in sera was significantly higher than that of CSF (t=9.974,P=0.000).Conclusion The concentration of ET-1 in CSF and sera in patients with acute craniocere-bral injury were associated with severe of brain injury .
