Discussion on clinical significance of the coagulation function detection of non small cell lung cancer patients
10.3969/j.issn.1671-8348.2014.04.018
- VernacularTitle:非小细胞肺癌患者凝血功能检测及临床意义探讨
- Author:
Mei YIN
;
- Publication Type:Journal Article
- Keywords:
carcinoma,non-small-cell-lung;
blood coagulation;
prognosis
- From:
Chongqing Medicine
2014;(4):424-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes and clinical significance of the coagulation function detection of non small cell lung cancer patients .Methods Selected 148 cases of non-small cell lung cancer admit of our hospital from 2011 January to 2013 April as the study group ,and 120 healthy persons as control group ,two groups were detected plasma prothrombin time (PT ) ,activated par-tial thromboplastin time(APTT) ,fibrinogen(Fib) ,platelet count(PLT) and D-dimer(D-D) .Results In the study group:PT exten-sion 8 cases(5 .4% ) ,APTT extension 27 cases(18 .2% ) ,Fib increased 80 cases(54 .1% ) ,PLT increased 25 cases(16 .9% ) ,PLT reduced 4 cases(2 .7% ) ,D-D increased 88 cases(59 .5% ) .APTT ,Fib ,PLT and D-D level in the study group was significantly high-er than the control group(P<0 .05) .No significant differences between the two groups of PT (P>0 .05) .Fib and D-D levels in stage Ⅳ NSCLC were significantly higher than patients with stage Ⅰ ~ Ⅲ lung cancer tumor metastasis ,Fib and D-D levels of pa-tients were significantly higher than those without metastasis patients (P<0 .05);for tumor size ,pathological type ,tumor differenti-ation degree unrelated to APTT ,Fib ,PLT ,D-D levels ,there were no difference statistical significance(P>0 .05) .Conclusion Pa-tients with lung cancer APTT ,Fib ,PLT ,D-D level increased significantly ,there is a close relationship between the prognosis of pa-tients w ith Fib and D-D levels and lung cancer .
