A clinical study of Chuanhu anti-gout mixture in the treatment of acute gouty arthritis
10.3760/cma.j.issn.1000-6699.2014.01.013
- VernacularTitle:穿虎痛风合剂治疗急性痛风性关节炎的临床研究
- Author:
Xiaolong YU
;
Yang LI
;
Enze LI
;
Changgui LI
;
Yan'gang WANG
;
- Publication Type:Journal Article
- Keywords:
Gout;
Arthritis;
Herb;
Non-inferiority test
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(1):49-51
- CountryChina
- Language:Chinese
-
Abstract:
In this double-blind,double-dummy,non-inferiority study,144 cases of newly diagnosed acute gouty arthritis were reassigned to Chuanhu anti-gout mixture group (CH,n =72) and colchicine group (Col,n =72).After treatment for 10 days,the total efficiency rates of CH and Col groups were 93.02％ and 95.35％,respectively,showing no difference between two groups.Three months later,the overall recurrence rates in CH and Col groups were 12.50％ and 13.89％ respectively (P＜0.05).The incidence of adverse reactions in colchicine group was significantly higher than CH group (34.72％ vs 2.78％,P ＜ 0.01).Blood uric acid,alanine aminotransferase,aspartate aminotransferase,and creatinine in CH group were decreased significantly compared with Col group (P＜0.05 or P＜0.01).The results suggest that the clinical efficacy of Chuanhu anti-gout mixture in the treatment of acute gouty arthritis was not inferior to colchicine,but with higher safety.
