Effects of alendronate sodium and alfacalcidol on parameters of atherosclerosis in old women with type 2 diabetes mellitus complicating osteoporosis
10.3969/j.issn.1671-8348.2013.25.002
- VernacularTitle:阿仑膦酸钠与阿法骨化醇对骨质疏松老年女性患者动脉硬化参数的影响
- Author:
Xiafei LI
;
Juan WU
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
osteoporosis;
alendronate sodium;
alfacalcidol
- From:
Chongqing Medicine
2013;(25):2955-2958
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of alendronate sodium and alfacalcidol on the parameters of atherosclerosis in old women with type 2 diabetes mellitus(T2DM ) complicating osteoporosis .Methods 28 old women with T2DM complicating osteopo-rosis were taken as the osteoporosis group and 25 old women with T2DM and without osteoporosis were taken as the control group .Alendronate sodium(70 mg/week) and alfacalcidol(0 .5 μg/d) were given to the osteoporosis group for 12 month .The pa-rameters of the bone mass density (BMD)of femoral neck and ,T value ,arkle brachial index (ABI) ,cardio-ankle vascular index (CAVI) and carotid artery intima-media thickness(IMT) ,blood fat and glycosylated hemoglobin were observed .Results Com-pared with the control group ,BMD ,T value and ABI in the osteoporosis group were significantly decreased (P<0 .01) ,while CAVI and IMT were obviously increased(P<0 .05) .Compared with before treatment ABI ,CAVI and IMT after 12 month treatment in the osteoporosis group had no significant changes ,but BMD and T value of femoral neck and ward triangle area were significantly increased(P<0 .05) ,the atherosclerosis degree after 12 months in the control group was significantly aggravated (P<0 .05) .BMD and T value had no obvious change .Conclusion Alendronate sodium combined with alfacalcidol for treating T 2DM complicating os-teoporosis can improve the atherosclerosis parameters and has certain role in preventing and treating cardiovascular and cerebrovas-cular diseases .
