Clinical features and correlation research of fever in systemic lupus erythematosus patients
10.3760/cma.j.issn.1007-7480.2011.10.003
- VernacularTitle:系统性红斑狼疮患者活动性发热特点及相关性分析
- Author:
Feng-hong YUAN
;
Ling-yun SUN
;
Wen-you PAN
;
Xiang-dang WANG
;
Jie-ping PAN
;
Miao-jia ZHANG
;
Yu ZHANG
;
Kui-lin TAN
;
Jing LI
;
Zhi-wei CHEN
;
Xiang DING
;
Xian QIAN
;
Zhan-yun DA
;
Juan TAO
;
Mei-mei WANG
;
Yao-hong ZOU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Fever;
Risk factor;
Retrospective studies
- From:
Chinese Journal of Rheumatology
2011;15(10):666-670
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical features of systemic lupus erythematosus (SLE) patients with fever and find out the related factors.MethodsData was collected by the same methods in the past ten years in fifteen hospitals in Jiangsu province and then the data wereretrospectively analyzed.The potentially possible risk factors of fever in SLE were selected and then analyzed by chi-square test,Wilcoxon rank sum test and Logistic regression analysis.ResultsAll 1762 patients were investigated.Seven hundred and twenty-nine had active fever.Age at hospitalization,initially treated patients,photosensitivity,serositis,nervous system involvement,generalized lymphadenopathy/hepatosplenomegaly,white blood cell count (WBC),haemoglobin (HB),erythrocyte sedimentation rate (ESR),C-reaction protein (CRP),alanine aminotransferase(ALT),albumin(ALB),serum creatinine (Scr),complement C3,anti-dsDNA antibodies positive rate,anti-Sm antibodies positive rate,SLEDAI score and past therapies were factors associatedwith SLE fever.Logistic regression analysis showed that abnormal WBC count (OR=1.396,95％CI 1.114-1.711,P=0.004),CRP(OR=1.005,95％CI 1.002-1.009,P=0.002),ALT(OR=1.003,95％CI 1.001-1.005,P=0.005),Scr (OR=0.997,95％CI0.995-0.999,P=0.007),HB (OR=0.986,95％CI 0.981-0.992,P=0.000),age (OR =0.984,95％ CI 0.974-0.993,P=0.001 ) and past usage of cyclophosphamide (CTX) (OR =0.557,95％CI 0.382-0.813,P=0.002) were correlated with SLE fever.ConclusionFever is one of the most common clinical manifestations of SLE patients.Leucopenia,elevated CRP levels,liver function abnormalities,anemia,younger age are risk factors for SLE fever,while renal impairment and past usage of CTX are protective factors.
