Expression and correlation of Hedgehog signaling pathway and LKB1 gene in breast cancer
10.3760/cma.j.issn.1673-422X.2011.09.010
- VernacularTitle:Hedgehog信号通路与LKB1基因在乳腺癌中的达及其相关性研究
- Author:
Xueying QU
;
Zhi-gang ZHUANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Signal transduction;
Genes,LKB1
- From:
Journal of International Oncology
2011;38(9):674-676
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog signaling pathway is excessive activated in breast cancer.LKBl is currently accepted as a tumor-suppressor gene,which can inhibit the proliferation of breast cancer.The overexpression of LKB1 can regulate the expression of CyclinDl series gene which is a target gene of Hedgehog signaling pathway.Meanwhile,the study found that PKA gene play an important role in Hedgehog signaling pathway,its activation is related with the cAMP state,and LKB1 genes can influence the cAMP state.Therefore,LKB1 gene and the Hedgehog signaling pathway may exist some inevitable connection.
