Telomere, Telomerase and Tumor
- VernacularTitle:端粒、端粒酶与肿瘤
- Author:
Ling ZHANG
;
Longyun LI
;
- Publication Type:Journal Article
- Keywords:
Telomere Telomerase Cancer
- From:
Basic & Clinical Medicine
1999;19(5):401-404
- CountryChina
- Language:Chinese
-
Abstract:
Telomere is the end structure of chromosome and it will be shortened during replication． Telomerase is a reverse transcripatse consisting of both RNA and protein components and synthesizes telomeric DNA by copying the template sequence of its own RNA components to maintain telomere length for function．Telomerase activity in germline cells，immortal and neoplastic cells was detected，but not in mostly normal cells．The telomere-telomerase hypothesis was brung out to explain this phenomenon．According to this hypothesis，re-actived telomerase will maintain telomere's length for protecting chromosome to make the cell immortal．The aging procedure will be explained by this hypothesis too．This hypothesis provides a new concepts of cancer and cancer's treatment．
