Expression of Epidermal Growth Factor, Transforming Growth Factor-αand Epidermal Growth Factor Receptor in Human Pituitary Tumors
- VernacularTitle:垂体瘤中EGF、TGF-α及其受体的表达
- Author:
Long ZHANG
;
Ting LEI
;
Delin XUE
;
- Publication Type:Journal Article
- Keywords:
Pituitary Tumor Epidermal Growth Factor Epidermal Growth Factor Receptor
- From:
Chinese Journal of Clinical Oncology
2000;27(11):805-807
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mechanism of growth factor autocrine stimulation in human pituitary tumors. Method: Immunohistochemical analyses of EGF、TGF-αand EGFR were studied on paraffin-embeded sections of 30 pituitary tumors. Results: Expression of EGFR and its ligand EGF、TGF-αhas a variable stained cells intensity,density and type. EGFR and the ligands expressed in majority of pituitary tumors.Conclusion:The EGF autocrine stimulation exists in pituitary tumors,and tyrosine kinases inhibitors may be useful for pituitary tumors treatment.
