Combined Chemotherapy of HCPT,MTX,Leucovorin and 5-Fu for Metastatic Breast Cancer
- VernacularTitle:羟基喜树碱、氨甲喋呤、5-氟脲嘧啶和醛氢叶酸联合化疗治疗晚期复发性乳腺癌
- Author:
Wei LIU
;
Weijian FENG
;
Ruihe YANG
;
- Publication Type:Journal Article
- Keywords:
HCPT HMLF regimen Metastatic breast cancer Combination chemotherapy
- From:
Chinese Journal of Clinical Oncology
2000;27(11):821-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The therapeutic efficacy and side effects of combined chemotherapy of HCPT,MTX,LV and 5-Fu for metastatic or recurrent breast cancer were evaluated in our study.Methods:A total of 43 cases of advanced metastatic or recurrent breast cancer were treated with chemotherapy regimen consisting of HCPT 10mg/m2 iv gtt for dl～5,MTX 100mg iv dl,Leucovorin 150mg/m2 iv gtt for d2～4,5-Fu 500mg/m2 iv gtt for dl～5.The cycle was repeated every 4 weeks,and 2 cycles were given as one course.Results:The overall CR+PR was 47%.One year survival rate was 54% and the median survival interval was 19 months.The main side effects were bone marrow suppression and gastrointestinal reaction.Conclusion:The combined chemotherapy regimen consisting of HCPT etc is beneficial for metastatic breast cancer.
