Fluorescence Property of Reaction Productsof Sparfloxacin with Halide and Its Application
- VernacularTitle:司帕沙星与卤素反应产物的荧光特性及其应用
- Author:
Liming DU
;
Zhefeng FAN
;
Quan′e GUO
;
- Publication Type:Journal Article
- From:
Chinese Journal of Analytical Chemistry
2001;29(3):249-252
- CountryChina
- Language:Chinese
-
Abstract:
The fluorescence characteristics of reaction products of sparfloxacin with halide (F, Cl, Br, I) have been studied. It was found that sparfloxacin was oxidized by nitrous acid then reacted with halide further to formstrong fluorescence substances in acid media. Their fluorescence intensitites enhanced with aggrandizing of atom radii of halides, which could emit the strong fluorescence 58～151 fold more than that of sparfloxacin itself. Thus a new sensitive method for the direct determination of sparfloxacin in human urine by derivative-synchronous fluorescence was presented. A plausible mchanism was proposed to explin this behavior.
