Expression and significance of p53,nm23 and p16 in Wilms' tumor of children
- VernacularTitle:抑癌基因P53,nm23,p16独立评价Wilms瘤患儿预后的可能性分析
- Author:
Jie SUN
;
Yeming WU
;
Guohua LIU
;
Wenzhu ZHANG
;
Zhongde ZHANG
;
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2001;5(16):154-155
- CountryChina
- Language:Chinese
-
Abstract:
We studied 22 Wilms'tumors of children immunohistochemically.We've found that the positive rate of p53 in slices was 31.8% (7),of nm23 was 50% (11),and of p16 was 86.4% (19).It suggested that mutation rate of p53 was high in tumors,expression of nm23 in favorite histology(FH)was higher than that in unfavorite histology(UFH) group,and p16 showed very high positive rate in tumors.All of the three showed no relation with sex,age,or pathological type.So each one may be useful in clinic to evaluate pathogenesis and prognosis.
