COGNITIVE AND MOTOR OUTCOME AFTER LONG-TERM GLOBUS PALLIDUS EXTERNA DEEP BRAIN STIMULATION TO TRANSGENIC HUNTINGTON'S DISEASE RAT
- VernacularTitle:长时程深部脑刺激外侧苍白球对转基因Huntington病大鼠认知和运动的影响
- Author:
Chunyan CAO
;
Yasin Temel
;
Arjan Blokland
;
Veerle Visser-Vandewalle
;
Harry W. M. Steinbusch
;
Shengdi CHEN
;
Zhenguo LIU
- Publication Type:Journal Article
- Keywords:
deep brain stimulation;
choice reaction time task;
transgenic Huntington's disease rat;
globus pallidus externa
- From:
Chinese Journal of Neuroanatomy
2006;22(3):275-280
- CountryChina
- Language:Chinese
-
Abstract:
In this study, we treated transgenic Huntington's disease (tgHD) model rat with deep brain stimulation (DBS) and evaluated the cognitive and motor outcome. The results showed that the surgery of implanting electrode improved cognition, increased correct rate and decreased response bias in choice reaction time (CRT) task, with similar extent on various genotypes. After long-term DBS to globus pallidus externa( GPe), correct rate was enhanced. The enhancement was genotype related. Additionally, the motor time and reaction time in CRT task reflecting the movement initiation kept the same value, but the chorea-form movement of homozygous rats was rectified prominently after the treatment of DBS. The present results demonstrated that the operation of long-term DBS to globus pallidus externa can improve the cognition and motor outcome of tgHD rats, which implied DBS operation might shed light on HD patients in the future.
