Application of Bayesian Methods for laboratory to clinical translation and for identifying hidden subpopulations
- VernacularTitle:贝叶斯方法在实验室研究向临床的转化以及辨识隐含亚群体中的应用
- Author:
David Z. D'Argenio
;
Xiao-ning WANG
;
Ze-xun ZHOU
- Publication Type:Journal Article
- Keywords:
antiretroviral drugs;
lamivudine metabolism;
population modeling;
mixture models
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2007;12(10):1114-1121
- CountryChina
- Language:Chinese
-
Abstract:
Modeling methodologies developed for studying pharmacokinetic(PK)/pharmacodynamic(PD) processes confront many challenges related in part to the severe restrictions on the number and type of measurements that are available from laboratory experiments and clinical trials, as well as the variability in the experiments and the uncertainty associated with the processes themselves. Bayesian methods have provided a framework for PK/PD modeling and drug development that can address some of the above-mentioned challenges. This paper presents two illustrations of the application of Bayesian methods: the first involves a population modeling study of the cellular kinetics of the antiretroviral compound Lamivudine in the PBMCs of HIV-1 infected adolescents; the second uses a population mixture modeling approach to identifying hidden subpopulations that can not be identified by available measured covariates.
