Hospital-acquired pneumonia due to acinetobacter baumannii in RICU- a report of 49 cases
- VernacularTitle:RICU医院获得性鲍曼不动杆菌肺炎49例临床分析
- Author:
Yi SU
- Publication Type:Journal Article
- Keywords:
Acinetobacter Baumannii;
Hospital-acquired pneumonia;
Risk factor;
Antibiotic resistance
- From:
Journal of Chongqing Medical University
2009;34(11):1584-1587
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the prevalence, antibiotic resistance and risk factors of Acinetobacter Baumannii hospital-acquired pneumonia (ABHAP) in Respiratory Intensive Care Unit (RICU) of our hospital for guidance of clinical prevention and treatment of ABHAP. Methods: Clinical information and results of Antibiotic susceptibility test for all of the patients with hospital-acquired pneumonia (HAP) in RICU of our hospital from May 2007 to October 2008 were collected. Antibiotic resistance and risk factors of ABHAP were analyzed retrospectively. Results: 159 patients suffered from HAP. Of which, 49 patients had ABHAP and accounted for 30.8% of all cases. Acinetobacter Baumannii was the second commonest pathogen of HAP. The resistance rate of Acinetobacter Baumannii strains to the third generation of Cephalosporin and Fluoroquinolone were over 90%. And the resistance rate to Imipenen was 42.7%. Pan-resistant rate was 23.5%. Univariate analysis showed that APACHEII score≥20, hospitalization in RICU ≥2 weeks,invasive mechanical ventilation, invasive mechanical ventilation ≥7 days, trachea intubation or tracheotomy, trachea intubation or tracheotomy ≥7 days and broad-spectrum antibiotic therapy ≥7 days were associated with BAHAP. Multivariate logistic analysis showed that hospital ization in RICU ≥2 weeks,invasive mechanical ventilation ≥7 days, APACHEII score ≥20 and broad-spectrum antibiotic therapy ≥7 days were independent risk factors of ABHAP. Conclusions: The present study found high incidence rate, severe drug-resistance and therapeutic difficulties of ABHAP in RICU. Shortening duration of hospitalization and invasive mechanical ventilation, rational use of antibiotics are helpful to prevent and treat ABHAP.
