Liver Function of Lymphoma Patients with Chronic HBV Infection after Chemotherapy
10.3969/j.issn.1000-8179.2009.21.003
- VernacularTitle:HBV感染与淋巴瘤患者化疗后肝功能损害的相关性分析
- Author:
chong'an XU
;
Lili XING
;
Yan LI
;
He SU
;
Na DENG
;
Yunpneg LIU
;
- Publication Type:Journal Article
- Keywords:
HBV;
Lymphoma;
Chemotherapy;
Liver function damage
- From:
Chinese Journal of Clinical Oncology
2009;36(21):1208-1212
- CountryChina
- Language:Chinese
-
Abstract:
Objective. To observe the effect of chemotherapy on hepatic function of lymphoma patients with chronic HBV infection. Methods; We used ELISA to detect the serum markers, of HBV and liver function in 207 lymphoma patients and 207 patients with other types of cancer (except pdmary hepatocellular cacinoma). Results: The incidence of HBV infection was higher in lymphoma cancer cases than that in the controlled cases (19.8% vs 9.7%, P=0.004). The incidence of abnormal liver function was higher in lymphoma patients with positive HBsAg than in lymphoma patients without HBsAg (58.5% vs 27.7%, P=0.000). The incidence of ab-normal liver function in lymphoma patients with postive HBsAg was higher than that in patients with other types of cancer with positive HBsAg (58.5 vs 30.0%, P=0.036). The abnormal liver function in lymphoma patients after chemotherapy was associated with HBV infection (P=0.000) but not correlated with age, sex, histological subtype, immune subtype, stage, ECOG PS, and hormone administration. Conclusion: Lymphoma patients with HBV are more likely to have liver function damage after emotherapy.