Mechanisms of HIV envelope-induced T lymphocyte apoptosis
10.1007/s12250-010-3148-7
- Author:
Zhi-Tao WAN
;
Xu-lin CHEN
- Publication Type:Journal Article
- Keywords:
HIV;
Envelope glycoprotein;
T lymphocyte;
Apoptosis
- From:
Virologica Sinica
2010;25(5):307-315
- CountryChina
- Language:Chinese
-
Abstract:
Infection by the human immunodeficiency virus (HIV) is characterized by a progressive depletion of CD4 T lymphocytes, which leads to dysfunction of the immune system. Although a variety of mechanisms may contribute to the gradual T cell decline that occurs in HIV-infected patients, abnormal apoptosis of infected or bystander T lymphocytes is an important event leading to immunodeficiency. The HIV envelope glycoprotein plays a crucial role in HIV associated apoptosis through both death receptor-mediated and mitochondria-dependent pathways. This review summarizes current knowledge of Env-mediated T lymphocyte apoptosis.
