Expression of MGMT and its clinopathological significance in thyroid carcinoma
10.3969/j.issn.1672-7347.2010.12.003
- VernacularTitle:MGMT蛋白在甲状腺癌中的表达及其临床意义
- Author:
Xiamixinuer·YILIKE
;
Gulinaer·KUERBAN
;
YANG Xi
;
WU Shuang
;
Abulizi·ABUDULA
- Publication Type:Journal Article
- Keywords:
thyroid cancer;
MGMT;
expression;
immunohistochemistry
- From:
Journal of Central South University(Medical Sciences)
2010;35(12):1219-1224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of O6-methylguanine-DNA methyltransferase (MGMT) and its clinicopathological significance in thyroid cancer.Methods Immunohistochemistry was used to determine the expression of MGMT in 61 thyroid cancer tissues, 21 thyroid adenomas, 15 Hashimoto's thyroiditis, 8 nodular goiter, and 12 peri-tumor tissues. Results There was statistic difference in the expression of MGMT between the normal tissues and thyroid cancers (P＜0.05). Expression of MGMT increased from the normal tissue (16.67%, 10/12), nodular goiter (25.00%, 2/8), Hashimoto's thyroiditis (60.00%, 9/15), and thyroid adenoma (52.38%, 11/21)to thyroid cancer (60.66%, 38/61). Expression of MGMT in papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) had significant difference (P＜0.05), and the expression level of MGMT decreased with the malignancy of thyroid cancer, such as in PTC (72.22%, 26/36), and FTC (50.00%, 8/16). There was no statistic difference in MGMT expression in sex, age, and nationality (P＞0.05).Conclusion High expression of MGMT might be related to the malignancy of thyroid cancer, which may be one of the diagnosis indexes for thyroid cancer. It will be a common clinical index in diagnosingthyroid cancer since there is no difference in MGMT expression among sexes, ages, and nationalities.
