Neuropsychiatric symptoms in Chinese children with systemic lupus erythematosus
- VernacularTitle:儿童系统性红斑狼疮神经精神症状的研究(一)
- Author:
Jing DONG
;
Jibo WANG
;
Lunghau YU
;
Tsz Leung Lee
;
Pamela Pui Wah Lee
;
Wilfred Hing Sang Wong
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Lupus vasculitis,central nervous system;
Child
- From:
Chinese Journal of Rheumatology
2008;12(12):829-832
- CountryChina
- Language:Chinese
-
Abstract:
Objective To define the clinical characteristics of NPSLE in Chinese children by analyzing their demographic data,clinical manifestations,laboratory parameters and treatment.Methods Sixtytwo children with SLE who were diagnosed between 1990 and 2006 were retrospectively reviewed.The demographic data,clinical manifestations,laboratory parameters,imaging and treatment were analyzed.The syndromes were compared with those reported in other studies.Results Nineteen (31%) SLE patients with 21 NP events were identified.The most common NP manifestations were cognitive dysfunction (48%),seizure disorder (43%) and headache (29%).The abnormality percentage of SPECT was 80%.86% patients received MP pulses therapy.Most (74%) patients recovered without long-term neurological complications.Conclusi NP symptoms are common in Chinese children with SLE,however,the prese-ntations are different from that reported in other studies.SPECT and MR are sensitive tests for NPSLE.The prognosis of NPSLE in our series is favorable.
