Effects of ZPSJ Recipe on Insulin Sensitivity,Serum Resistin and Inflammatory Factors in Type 2 Diabetic Patients with Insulin Resistance
10.3760/cma.j.issn.1673-4246.2009.04.005
- VernacularTitle:ZPSJ方对2型糖尿病胰岛素抵抗患者胰岛素敏感性的影响
- Author:
Yong-chang DIWU
;
Rong CHEN
;
Jie GAO
- Publication Type:Journal Article
- Keywords:
ZPSJ Recipe;
Insulin resistance;
Resistin;
Inflammatory factors
- From:
International Journal of Traditional Chinese Medicine
2009;31(4):299-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Observe the influence of Zaoshi Jiedu Zhupi Sanjing (ZPSJ) Recipe on insulin sensitivity, serum resistin and inflammatory factors related to the effects of Chinese herbal compound in type 2 diabetic patients with insulin resistance. Methods A single-blind randomized controlled clinical trial was conducted. 80 patients with 2 type diabetic patients with insulin resistance were recruited into a control group and a treatment group. The treatment group was treated with ZPSJ Recipe, and the control group was treated with metformin. Results In each group before and after treatment: blood glucose, serum insulin levels, HOMA-IR were significantly decreased (t=7.14, P<0.01 ) ; between the two groups, FPG, FINS showed no significant difference, while TG TCH, HOMA-LR showed significantly differences (t=2.62, P <0.05 ). Within the two groups before and after the treatment: serum IL-6, TNF-a, hs-CRP were decreased in treatment group, (t= 1.85, P<0.05 ) , while TNF-a, hs-CRP were decreased in the control group (t=2.56, P<0.05 ) , while IL-6 did not change significantly. The serum resistin levels were not statistically changed in both groups before and after treatment. Conclusion ZPSJ Recipe can regulate blood sugar, blood fat and improve insulin sensitivity in type 2 diabetic patients with insulin resistance.
