Bmil gene in stem cells and tumorigenesis

VernacularTitle:Bmi1基因在干细胞和肿瘤发生中的作用
Author: Rui ZHANG ; HU-CHAO ;
Publication Type:Journal Article
Keywords: Stem cells; Bmil gene; Neoplasms
From: Journal of International Oncology 2009;36(11):806-809
CountryChina
Language:Chinese
Abstract: Stem cells are characterized by the ability to renew themselves and differentiate into a di-verse range of specialized cell types.Bmi1 gene has been determined to play critical roles in the self-renewal of stem cells.Many of the tumor originated in stem cells.Enhanced self-renewal capability in stem/progenitor cells changes its biological characteristic and drives tumor initiation