Influence of TangNaiKang on VEGF protein expression of GK rats thoracic aorta

VernacularTitle:糖耐康对大鼠胸主动脉血管内皮生长因子蛋白表达的影响
Author: Xiang-yu GUO ; Ying DUAN ; Zhi-cheng WANG ; Jie NIU ; Li-xia YANG ; Juane LI ; Tong-hua LIU ;
Publication Type:Journal Article
Keywords: TangNaiKang; GK rats; VEGF; Diabetic vascular disease
From: International Journal of Traditional Chinese Medicine 2010;32(3):200-202
CountryChina
Language:Chinese
Abstract: Objective To investigated the effect of TangNaiKang (TNK) on VEGF protein expression of GK rats Thoracic aorta. Methods 51 male GK rats were divided into five groups randomly: model group, pioglitazone group, and TNK treatment group (low, immediate and high dose). Another 10 male Wistar rats were served as normal control group. GK rats were fed with high-grease forage, while normal control group was fed with a standard diet. Fasting blood glucose, general HE staining and VEGF protein expression were detected by immunohistochemistry. Results The fasting glucose had a significant decline in TNK treatment groups. HE staining showing TNK can ameliorate intima thickness, reduce hyperplasia of shallow vascular smooth muscle cell, and improve wavy and plexiform arrangement of elastic lamina. Immunohistochemistry also showed that TNK decreased VEGF protein expression of great vessels. Conclusion TangNaiKang can prevent and cure diabetic vascular complication of GK rats.