Correlative factors of the hydatidiform mole deterioration and clinical significance of matrix metalloproteinase 9 in gestational trophoblastic disease
10.3760/cma.j.issn.1673-4904.2010.12.002
- VernacularTitle:葡萄胎恶变相关因素的探讨及基质金属蛋白酶-9在妊娠滋养细胞疾病中表达的临床意义
- Author:
Li DING
;
Xia WANG
;
Li-xia SUN
- Publication Type:Journal Article
- Keywords:
Hydatidiform mole;
Matrix metalloproteinase 9;
Gestational trophoblastic neoplasms;
Deterioration
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(12):4-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the possibility of prognosing the hydatidiform mole deterioration and metastasis by detecting the expression of matrix metalloproteinase 9(MMP-9)in different type of trophoblastic disease,and analyze the correlative factors of the hydatidiform mole deterioration,so as to improve the criterion of hydatidiform mole prognosis.Methods The expression of MMP-9 in 30 cases of normal human(Iess than 12 weeks)cytotrophoblast cells,32 cases of partial hydatidiform mole,93 cases of complete hydatidiform mole,30 cages of invasive mole and 5 cases of choriocarcinoma were detected by immunohistochemical streptavidin-pemxidase.The factors as the age of onset,uterine size,luteinizing cyst,β-human chorionic gonadotropin hCG of 7 cases of the hydatidiform mole deterioration were analyzed.Results The expression of MMP-9 was detected in all types of trophoblastic cells,with the development of the malignant transformation the stainning Was markedly increased in the invasion of the normal human cytotrophoblast cells(X2=23.49,P＜0.05).Conclusion The difference of MMP-9 expressin gestational trophoblasts is helpful to predict the hydatidiform mole deterioration and metastagis,the hydatidiform mole deterioration correlates with the age of onset,β-hCG,uterine size,luteinizing cyst.
