Prediction of sensitization for recipients of renal transplant and its clinical implication
- VernacularTitle:肾移植受者致敏状态的预测及其临床意义
- Author:
Liuyang LI
;
Wei GAO
;
Xiwen WANG
;
- Publication Type:Journal Article
- Keywords:
Panel reactive antibody;
Random panel lymphocytotoxicity test;
Plasma exchange
- From:
Chinese Journal of Organ Transplantation
1997;18(4):234-236
- CountryChina
- Language:Chinese
-
Abstract:
The level of HLA-antibody and sensitization can be predicated by the determination of panel reactive antibody(PRA)which is of great significance in preventing hyperaeute and accelcrated rejection.The sensitivity of PRA is markedly higher than CDC.The level of PRA(positive rate above 50%)is closely relevant,to the degree of rejection and the decrease of graft survival.Although plasma exchange(PE)can be used to decrease the level of PRA before transplantation to prevent hyperacute and accelerated rejection,good HLA-matching is more important in securing a successful graft patient.Control study between random panel lymphocytotoxicity test(RPLT)and PRA showed that RPLT is a simpler and more dependent and more easily practised method to predict the sensitivity of recipients of renal transplantation.
