Expression and correlation of NKG2D and sMICA in lung cancer patients
10.3760/cma.j.issn.1006-9801.2009.11.014
- VernacularTitle:肺癌患者自然杀伤细胞活性受体NKG2D与可溶性MICA的表达及其相关性分析
- Author:
Gang CHEN
;
Chun-li WANG
;
Shi-ping GUO
;
Wen SU
;
Li-juan QIAO
;
Xian-xia MAI
;
Jie MA
;
Cheng-guang HU
;
Pei-gang ZHANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Receptors;
neurokinin-2;
Genes;
MHC class I;
Immune escape;
tumor
- From:
Cancer Research and Clinic
2009;21(11):759-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and correlation of NKG2D and sMICA in lung cancer patients. Methods By collecting 30 lung cancer patients as the test group,and taking 30 healthy volunteers as the contrast group, the expression of NKG2D and sMICA in the two groups were examined separately by FACS and ELISA method. Results The expressions of NKG2D in the two groups were (81.56±8.78) %, (85.63±6.62) %. The lung cancer patients were high remarkable. There was a significant difference between the two groups (P <0.05). The expression of sMICA in the two groups were (354.13 ±80.575) pg/ml,(216.53±48.175) pg/ml. The lung cancer patients were low remarkable. There was a significant difference between the two groups (P <0.01). There was a significant relation between the two groups (r =-0.349, P =0.006). Conclusion The expression of NKG2D and sMICA may provid one of the immune targets for diagnosing that can forecast the immune state and malignant metastasis of the lung cancer patients. The significant relation between NKG2D and sMICA may take on main role in the immune escaping of tumor. It may provide the suitable target of the patients for tumor organisms and immune treatment.
