A Progress on the Key Technologies for Discovery of Bioactive Compounds from Traditional Chinese Medicines

VernacularTitle:中药活性成分发现关键技术研究进展
Author: Huipeng SONG ; Hua YANG ; Wen GAO ; Jun CHEN ; Ping LI
Keywords: Bioactive compounds of traditional Chinese medicines; screening technology; integration effect; lead compound; bioactive equivalent combinatorial components
From: World Science and Technology-Modernization of Traditional Chinese Medicine 2016;18(7):1093-1098
CountryChina
Language:Chinese
Abstract: Traditional Chinese medicines (TCM) is one of the most important sources of new drugs.The rapid development of modern science and technology has brought new opportunities for TCM.Admittedly,new academic theory is getting into a golden period of innovation.Key technologies that enbody TCM features and adapt to modern drug-screening requirements are urgently needed.After five years' endeavor,the authors' group has made great progress in the new theories and methodologies for the discovery of bioactive compounds from TCM.In this review,a total of five key technologies:library-bioactivity-structure integration,biological and chemical fishing technology,ligand-and receptor-based virtual screening,profile-bioactivity relationship and the technology for discovering bioactive equivalent combinatorial components (BECCs),were introduced.In the text,several valuable demonstrations over the TCM-based drug discovery were provided,for uncovering the scientific basis of TCM and accelerating the process of TCM modernization.