A Research Progress on Matrine and Its Preparations
10.11842/wst.2016.07.003
- VernacularTitle:苦参碱及其制剂的研究进展
- Author:
Huan HE
;
Xinyue SHANG
;
Shaojiang SONG
- Keywords:
Matrine;
preparation;
research progress
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2016;18(7):1099-1107
- CountryChina
- Language:Chinese
-
Abstract:
Matrine is an effective natural product isolated from the traditional herb,Sophora flavescens,with wide range of pharmacological and clinical effects and treating as the treatment for chronic viral hepatitis in clinic.Currently,the mainstream clinical preparations of matrine involved injections,tablets,capsules and suppositories,while preparations under development included targeting preparations,sustained-release preparations and transdermal drug delivery preparations.Admittedly,It can significantly improve the biological utilization of matrine through the optimization of its clinical preparations for with scientific researches and the development of new dosage forms.While the clinical applications will be expanded and the clinical efficacy of the preparations of matrine enhanced with the development of researches for new dosage forms and drugs and the application of new materials.It may be also benefical to the study of monomer compositions of Chinese material medica,including the development of the preparation of matrine.Rested on the recent studies,pharmacological activities,preparation methods and researches for the preparations of matrine was summarized in this text for providing a reference for developing its preparations in the future.
