Symptomatic characteristics and factors related to severity of irritable bowel syndrome
10.3760/cma.j.issn.1671-7368.2017.09.004
- VernacularTitle:肠易激综合征患者症状特点及严重程度影响因素分析
- Author:
Wenjuan FAN
;
Min CHANG
;
Xiaoqing LI
;
Liming ZHU
;
Guijun FEI
;
Xiucai FANG
- Keywords:
Irritable bowel syndrome;
Severity of illness index;
Comorbidity
- From:
Chinese Journal of General Practitioners
2017;16(9):668-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze symptomatic characteristics and the factors related to severity of irritable bowel syndrome (IBS).Methods Total 516 IBS patients met Rome Ⅲ criteria were enrolled in the study from June 2009 to February 2016.A questionnaire survey was conducted in face-to-face manner,including intestinal and extra-intestinal symptoms,sleeping and psychological status.Severity of IBS was determined by symptom scores.Results Among 516 patients,there were 135 cases with mild symptoms (26.2%),267 with moderate symptoms (51.7%) and 114 with severe symptoms (22.1%).Periumbilical pain/discomfort associated with defecation was a common symptom location (34.6%,178/516),however,53.3% (275/516) patients also reported having abdominal pain/discomfort during non-defecation period.In IBS patients,51.2% (264/516) were coexisted with gastroesophageal reflux disease (GERD),59.1% (305/516) with functional dyspepsia (FD),and 46.9% (242/516) with depression.The prevalence of ordinary abdominal pain/discomfort [57.0% (217/381) vs.43.0% (58/135),x2 =7.841],sensation of incomplete defecation[74.5% (284/381)vs.61.5% (83/135),x2 =8.277] and coexisted GERD[54.1% (206/381) vs.43.0%(58/135),x2 =4.920],FD[64.0%(244/381)vs.45.2% (61/135),x2 =14.664],headache[50.7% (193/381)vs.38.5% (52/135),x2 =5.889] and depression[52.2% (199/ 381)vs.31.9% (43/135),x2 =16.623] in patients with moderate to severe symptoms were significantly higher than that in patients with mild symptoms (all P < 0.05).The predictors to moderate-severe IBS symptoms were coexisted FD (OR =1.798,95% CI:1.162-2.783,P =0.010) and depression (OR =1.696,95% CI:1.043-2.759,P =0.014).Conclusion The symptoms of IBS patients are various,and patients coexisted with FD and depression are more likely to have more severe symptoms.