Study on the Preparation Process of Zhenjing Xiehuo Granules
- VernacularTitle:镇惊泻火颗粒的制备工艺研究
- Author:
Zhijun XI
;
Liwen XU
;
Xiufeng SHI
;
Wen QI
;
Jianshen TAO
;
Canxing YUAN
- Publication Type:Journal Article
- Keywords:
Zhenjing Xiehuo granules;
Extraction process;
Alcohol precipitation process;
Granule preparation proces
- From:
China Pharmacist
2015;18(12):2058-2061,2094
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the preparation procedure of Zhenjing Xiehuo granules. Methods: Using the dry extract yielding rate and the contents of liquiritin and salvianolic acid B as the indices, an orthogonal test was adopted to choose the best ex-traction and purification technology. Using the qualified ratio of granules as the index, an orthogonal test was adopted to choose the best preparation process of the granules. Results:The optimized preparation conditions were as follows:Pulvis ferri was decocted first for 60 min. The other medicines were dipped in 8-fold amount of water for 90 min, and then added into pulvis ferri extracts and decocted for 3 times with 90 min for each time. The extracts were collected and concentrated till the relative density was 1. 3 (measured at 60℃), water was added with the dilution ratio of 1:2, ethanol was added till the percentage of ethanol was 50%, and then the mixed liquid was filtered after 24 hours. After ethanol was recycled from the filtrate, the filtrate was concentrated till the relative density was 1. 3 (measured at 60℃), and then dried at 60℃. Starch as the diluent, the ratio of extract to excipient was 1:0. 8, and the wet granules were prepared with 90% ethanol as the wetting agent, dried 3 hours at 60℃ followed by size stabilization to obtain the products. Con-clusion:The optimized preparation procedure of Zhenjing Xiehuo granules is stable and feasible.
