Preparation and in vitro Release of Metoclopramide Orally Disintegrating Tablets
- VernacularTitle:甲氧氯普胺口崩片的制备及体外溶出度考察
- Author:
Xiangyang XIE
;
Shiguang ZHOU
;
Wen LIN
;
Chuanfeng XING
;
Chen CHEN
;
Ying CHEN
- Publication Type:Journal Article
- Keywords:
Metoclopramide;
Orally disintegrating tablets;
Full-factorial experiment design;
Friability;
Disintegration time;
Dis-solution
- From:
China Pharmacist
2015;(11):1882-1884,1894
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare and optimize the formula of metoclopramide orally disintegrating tablets, and investigate the in vitro drug dissolution behavior. Methods:The formula was optimized by full-factorial experiment design, the ratio of mannotil to micro-crystalline cellulose ( X1 ) and the amount of disintegrating agent ( X2 ,%) were selected as the independent variables, and the friabili-ty ( Y1 ,%) , disintegration time ( Y2 , s) and metoclopramide dissolution ( Y3 ,%) were used as the dependent variables. The release rate of metoclopramide orally disintegrating tablets in different dissolution media was studied. Results:The optimum formula of meto-clopramide orally disintegrating tablets was as follows:the ratio of mannotil to microcrystalline cellulose was 2. 5∶ 1, and the amount of disintegrating agent was 6. 5%. The dissolution of metoclopramide orally disintegrating tablets in the different dissolution media was o-ver 80%. Conclusion:The formula design is reasonable, the preparation process is feasible and the quality can be controlled.
