Determination of Compound Codeine Phosphate Oral Preparations by Capillary Electrophoresis
- VernacularTitle:毛细管电泳法测定复方磷酸可待因口服制剂的含量
- Author:
Zhenyu ZHOU
;
Bingren GU
- Publication Type:Journal Article
- Keywords:
Capillary electrophoresis;
Compound codeine phosphate oral preparations;
Determination
- From:
China Pharmacist
2015;(8):1312-1314,1315
- CountryChina
- Language:Chinese
-
Abstract:
To establish a method for the simultaneous determination of the active ingredients ( codeine phosphate, brompheniramine maleate, chlorpheniramine maleate, ephedrine hydrochloride and guaifenesin) in compound codeine phosphate oral preparations by capillary electrophoresis ( CE) . Methods:The method employed an uncoated capillary column ( eCAPTM ) from Beck-mann company (50 cm × 75 μm);the electrophoresis voltage was at 10 kV;20 mmol·L-1 phosphate buffer solution (pH 7. 5) was used;the UV measurement was at the wavelength of 214 nm. Results: The studied components had good linear ranges (r≥0. 995) within the range of the investigated concentrations. The recovery was no less than 96%. Conclusion:The presented method can be ap-plied in the content determination of active ingredients in compound codeine phosphate oral preparations from different enterprises. It is simple, efficient and universal, which facilitates the market supervision in a fast and valid manner.
