Clinical Observation of Sertraline in the Treatment of Diabetes Patients Complicated with Depression
- VernacularTitle:舍曲林治疗糖尿病合并抑郁患者的临床观察
- Author:
Guofang ZHU
;
Yingying DONG
;
Jianying XU
- Publication Type:Journal Article
- Keywords:
Sertraline;
Diabetes;
Depression
- From:
China Pharmacist
2015;(4):616-617,643
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect and safety of sertraline tablets with oral administration in the diabetes patients com-plicated with depression. Methods:Totally 74 diabetes patients complicated with depression were randomly divided into 2 groups with 37 ones in each. All the patients were orally given dimethyldiguanide 500 mg,tid,and the observation group was given sertraline tablets additionally,50-100 mg,qd. The treatment course was 8 weeks. The changes of sugar metabolism and the scores of self-rating depres-sion scale( SDS)and quality of life scale( DMQLS)in the two groups were compared. Results:After the 8-week treatment,the blood sugar,SDS scores and DMQLS scores in the two groups were significantly improved when compared with those before the treatment( P<0. 05). The levels of FBG,2hPG and HbAlc and SDS scores in the observation group were significantly lower than those in the con-trol group(P<0. 05),while the scores of DMQLS disease,psychology,society and satisfaction dimension were significantly higher in the observation group(P<0. 05). The incidence of adverse reactions showed no statistically significant difference between the two groups(P>0. 05). Conclusion:Sertraline tablets can improve the depression of diabetes patients and enhance the blood sugar control and quality of life.
