Study on distribution in rats and targeting property of flurbiprofen axetil microemulsion
- VernacularTitle:氟比洛芬酯微乳注射液大鼠组织分布及靶向性研究
- Author:
Lan ZUO
;
Xu CHEN
;
Weilin GUO
;
Gao LI
- Publication Type:Journal Article
- Keywords:
Flurbiprofen;
Tissue distribution;
Targeting;
Analgesia
- From:
China Pharmacist
2015;(6):932-935,977
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the distribution of flurbiprofen axetil ( FA) microemulsion in rats and evaluate the targeting prop-erty to traumatic inflammation tissue. Methods:Traumatic injury model rats were established by hip surgery on the rat right thigh mus-cle and randomly divided into 2 groups:microemulsion group and solution group. Serums and tissues of rats were collected at 15, 30, 60, 120 and 240min after administration (iv. 5 mg·kg-1). A high performance liquid chromatography (HPLC) with UV detection was developed to study the concentration of flurbiprofen in biological samples. Results: The elimination of flurbiprofen axetil microe-mulsion from blood and tissues was slower than flurbiprofen solution. At each 5 time points, drug concentrations of microemulsion group in injury muscle were higher than in normal muscle (P<0. 05), while solution group had no significant difference(P>0. 05). Micro-emulsion group injury muscle Te(targeting efficiency) =12. 21%, and the solution group Te =3. 97%. The Re (relative uptake rate) of injury muscle was 4. 15. Conclusion:The flurbiprofen axetil microemulsion has the targeting property to traumatic injury tissues.
