Efficacy Comparison of Misoprostol Administrated with Two Routes in the Prevention of Postpartum Hem-orrhage
- VernacularTitle:米索前列醇两种给药途径预防产后出血的疗效比较
- Author:
Yi CHEN
;
Wei CHEN
;
Furong JIN
- Publication Type:Journal Article
- Keywords:
Misoprostol;
Route of administration;
Postpartum hemorrhage
- From:
China Pharmacist
2015;(6):973-974,975
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effect of misoprostol respectively with sublingual administration and rectal administration in the treatment of postpartum hemorrhage. Methods:Totally 72 pregnant women were randomly divided into two groups with 36 cases in each. The sublingual group was given misoprostol 600 μg under the tongue immediately after the front shoulder of baby was delivered, while the rectal group was given misoprostol 600μg into rectum deeply. The amount of blood loss in 2 hours and 24 hours after the de-livery and the adverse reactions were compared between the two groups. Results: The postpartum hemorrhageon in 2 hours and 24 hours of the sublingual group was significantly less than that of the rectal group, and the incidence of postpartum hemorrhage in the sub-lingual group was significantly lower than that of the rectal group, and the difference was statistically significant (P<0. 05). After the treatment, the incidence of adverse reactions between the two groups had no significant difference (P>0. 05). However, the incidence of shiver in the sublingual group was significantly higher than that in the rectal group, and the difference was statistically significant ( P<0. 05). Conclusion:The preventive effect of misoprostol with sublingual administration on postpartum hemorrhage after natural vagi-nal delivery is better than that with rectal administration, which is safe and convenient, and worthy of promoted application in clinics.
