Association of HLA-B*1502 Genetic Polymorphism with Cyclosporine-induced Liver Injury in Chinese Re-nal Transplant Recipients
- VernacularTitle:HLA-B?1502基因多态性与肾移植受者环孢素所致肝功能异常的相关性研究
- Author:
Huawen XIN
;
Huiming LIU
;
Yuanqi LI
;
Hui HUANG
;
Li ZHAO
;
Airong YU
;
Qing LI
;
Xiaochun WU
;
Weiliang LI
;
Lei XIONG
- Publication Type:Journal Article
- Keywords:
Renal transplant;
Cyclosporine;
Liver injury;
HLA-B?1502 gene;
Polymorphism
- From:
China Pharmacist
2015;(5):704-706,707
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of HLA-B?1502 genetic polymorphism on cyclosporine( CsA)-induced liver injury in Chinese renal transplant recipients. Methods:HLA-B?1502 genotypes were determined by polymerase amplification chaln reaction of sequence-specific primers( PCR-SSP) in a total of 339 renal transplant recipients receiving CsA. All the subjects were divided into the CsA-induced liver injury group, non-CsA-induced liver injury group and the control group according to the liver injury occurrence. Results:In the 339 renal transplant recipients, the frequency of HLA-B?1502 mutation allele was 22. 64%. The distribution frequen-cy of HLA-B?1502 mutation allele had no significant difference among the three groups. There were no significant differences in the clinical characteristics of HLA-B?1502 genotypes among three groups(P>0. 05). Conclusion: No association is observed between HLA-B?1502 genetic polymorphism and cyclosporine-induced liver injury in Chinese renal transplant recipients.
