Clinical Effects of Meropenem in the Treatment of Severe Bacterial Lung infection
- VernacularTitle:美罗培南治疗重症细菌性肺部感染疗效观察
- Author:
Shuxia WU
;
Yonglong ZHAO
- Publication Type:Journal Article
- Keywords:
Meropenem;
Cefoperazone / sulbactam;
Severe bacterial lung infection;
Efficacy
- From:
China Pharmacist
2015;(5):812-813,814
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical effects and adverse reactions of meropenem in the treatment of severe lung infection. Methods:Totally 62 severe bacterial lung infection patients were randomly divided into two groups randomly. The patients in the con-trol group (31 cases ) were treated with cefoperazone / sulbactam 2-8 g in 100 ml 0. 9% sodium chloride injections,ivd,q12h, and the treatment group (31 cases ) was treated with meropenem 1 g in 100 ml 0. 9% sodium chloride injections,ivd,q8h. The treatment course was 14 days. The bacterial clearance rate, dual infection rate, clinical efficacy and adverse drug reactions of the two groups were observed and compared. Results:The bacterial clearance rate in the control group was 85. 2% and that in the treatment group was 92. 85% (P>0. 05). The incidence rate of dual infection in the treatment group (3. 6%) was significant lower than that in the control group (P<0. 05). The total effective rate in the treatment group (96. 77%) was significant higher than that in the control group ( P<0. 05). The adverse reactions of the two groups had no significant difference (P>0. 05). Conclusion:Meropenem is ef-fective in the treatment of severe bacterial lung infection. It can clear bacteria and reduce dual infection effectively, which shows better efficacy than cefoperazone / sulbactam.
