Research on the Treatment of Depression with Sleep Disorders by Paroxetine Combined with Olanzapine
- VernacularTitle:帕罗西汀联合奥氮平治疗抑郁症并发睡眠障碍临床观察
- Author:
Zhengping CHEN
;
Guanmao YU
;
Jianfeng GUO
- Publication Type:Journal Article
- Keywords:
Paroxetine;
Olanzapine;
Depression;
Sleep disorders
- From:
China Pharmacist
2015;(2):273-274,275
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy and adverse reactions of paroxetine combined with olanzapine in the treat-ment of depression complicated with sleep disorders. Methods: Totally 150 cases of sleep disorder patients were selected, and then randomly divided into the control group and the observation group with 75 ones in each. The control group was given paroxetine treat-ment, the observation group was given paroxetine combined with olanzapine treatment, and the treatment course was four weeks. The sleep latency, total sleep time, wake-up time and the number of awakening in the two groups were recorded, and the HAMD scale score and treatment efficacy were compared. Results:Compared with those in the control group, the sleep latency, total sleep time, wake-up time and the number of awakening in the observation group were obviously improved (P<0. 05). The clinical cure rate, the HAMD scale score and the incidence of adverse reactions between the two groups all had significant differences (P<0. 05). Conclu-sion:Paroxetine combined with olanzapine in the treatment of depression with sleep disorders shows fast efficacy, which can improve the sleep disorder symptoms and reduce the incidence of adverse reactions significantly.
