Dissolution Determination of Cephalexin from Different Preparations by Optical Fiber in-Situ Process Anal-ysis
- VernacularTitle:光纤传感过程分析不同剂型头孢氨苄的溶出度
- Author:
Shumei YANG
;
Wen HE
;
Xin LI
- Publication Type:Journal Article
- Keywords:
Cephalexin;
Different dosage forms;
Dissolution;
Optical fiber in-situ process analysis
- From:
China Pharmacist
2015;(3):381-383,384
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop a UV optical fiber in situ process monitoring method for the dissolution behavior of five cepha-lexin solid dosage forms and compare the drug dissolution behavior of different cephalexin preparations. Methods: The dissolution of five different cephalexin preparations was on-line monitored according to the dissolution method for cephalexin tablets in Chinese Phar-macopeia (2010 edition) combined with a six channel optical fiber chemical sensor in situ dissolution monitor. Results:The dissolu-tion curves could show the drug release characteristics of different cephalexin preparations, and the five different preparations exhibited various drug release features. Conclusion:An in-situ, real time, on-line and process analysis of dissolution can be obtained by optical fiber dissolution test system automatically. The release characteristics of different preparations can be presented through dissolution curves directly, which can provide reference for the overall assessment of drug internal quality and clinical medication.
