Progress in ATP-competitive Kinesin Spindle Protein Inhibitors as Anticancer Agents
- VernacularTitle:用于抗肿瘤的ATP竞争性纺锤体驱动蛋白抑制药的研究进展
- Author:
Dongcheng TANG
;
Xuesun HUANG
;
Jinlai LIU
;
Cheng JIANG
- Publication Type:Journal Article
- Keywords:
Kinesin spindle protein inhibitors;
ATP-competitive;
Anti-cancer
- From:
China Pharmacist
2015;(3):420-423,426
- CountryChina
- Language:Chinese
-
Abstract:
Kinesin spindle protein ( KSP) inhibitors is an important direction for the discovery of anticancer agents. Several KSP in-hibitors have been studied in clinic trials. The discovery of ATP-competitive KSP inhibitors may be a new approach for searching novel a-gents to overcome the mutation-mediated resistance to the allosteric inhibitors. The progress in the discovery of ATP-competitive KSP in-hibitors was reviewed in the paper to provide reference for the further development of KSP inhibitors.
