CONNECTIONS BET WEEN VESICULAR GLUTAMATE TRANSPORTERS-,GAD-LIKE IMMUNOREACTIVE TERMINALS AND GABA_A RECEPTOR ?3 SUBUNIT- LIKE POSITIVE NEURONS IN MESENCEPHALIC TRIGEMINAL NUCLEUS OF THE RAT
- VernacularTitle:大鼠囊泡膜谷氨酸转运体样和谷氨酸脱羧酶样阳性终末与表达GABA_A受体?3亚单位的三叉神经中脑核神经元之间的联系(英文)
- Author:
Peng CHEN
;
Lian LIJIN
- Publication Type:Journal Article
- Keywords:
Trigeminal proprioception;
Mesencephalic trigeminal nucleus;
Vesicular glutamate transporter;
GABA;
Immunofluoresence histochemistry;
Rat
- From:
Acta Anatomica Sinica
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the association of vesicular glutamate transporter of typeⅠ (VGluT1 ) like immunoreactive(LI) ,the differentiation-associated Na+ dependent inorganic phosphate cotransporter(DNPI) LI and glutami cacid decarboxy lase(GAD) LI terminals with GABAA receptor ?3 subunit(GABAAR ?3) LI neurons in mesencephalic trige minal nucleus of the rat.Methods Triple immun of luorescencehis to chemical staining technique and confo call aser scanning micros copy were used.Results Alargenumber of neuronal cell bodies showed GABAA R?3 LI immunoreactivity atallrostrocaudal level softhe Vme ,and most of GABAAR ?3 LI cells were large (2 5 5 0 ?m)pseudouni polarneurons.The dense VGluT1 LI,DNPL LI and GAD LIterminal sdistri buted widelyin Vme ,some VGlu T1 DNPI LI and GAD LIterminals surrounded the somata of the GABAAR ?3 LI Vmeneurons ,and made close contacts with them .Conclusion Proprioceptive sensory signals from the or of acialregionmight be modulated at the level of the primary afferent cell bodies in the Vme both by glutamatergic and GABAergic axonal terminals from other brain areas,and the effect of GABAergic terminals might be mediated by post synaptical GABAA receptors .
