Expression of CXCL9 in oral submucous fibrosis and oral lichen planus
- VernacularTitle:趋化因子9在口腔黏膜下纤维化和口腔扁平苔藓中的表达及意义
- Author:
Ning LI
;
Xinchun JIAN
- Publication Type:Journal Article
- Keywords:
Oral submucous fibrosis;
Oral lichen planus;
Immunohistochemistry;
Western blotting
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of CXCL9 in oral submucous fibrosis (OSF) as well as oral lichen planus (OLP) and its role in the inflammatory and immunological reaction. Methods:The expression of CXCL9 was examined in 66 OSF specimens,17 OLP specimens and 10 normal buccal mucosa tissues by immunohistochemistry,and the protein level of CXCL9 were detected by Western blotting.Results:43 (65.2%) cases of OSF and 16 (94.1%) cases of OLP showed positive immunoreactivity for CXCL9 in the cytoplasm of inflammatory cells and endothelial cells. All normal buccal mucosa tissues stained negative for CXCL9. The expression levels of CXCL9 in OLP and OSF were significantly higher than that of normal controls,and the expression level in OLP was significantly higher than in OSF(?2= 4.20,P
