Clinical study of the sustained-release ibuprofen gel for treatment of chronic periodontitis
- VernacularTitle:布洛芬缓释凝胶治疗慢性牙周炎的临床研究
- Author:
Zhenwei HOU
;
Hexiang BAI
;
Fenghua ZHANG
- Publication Type:Journal Article
- Keywords:
Chronic periodontitis;
Ibuprofen;
Gel;
Drug release
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the feasibility of sustained-release ibuprofen gel as a new local drug and its efficacy in the treatment of chronic periodontitis.Methods:Sustained-release ibuprofen gel was manufactured with PLGA as sustained-release adjuvant.Its release in vitro was tested by UV-spectrophotometer.60 teeth from 30 chronic periodontitis patients were chosen.Each patient had two teeth which were similar.The two teeth of every patient were divided into experiment group and control group.After scaling and root planning the sustained-release ibuprofen gel was injected into the pocket in the experiment group every week,two times in all.While those in the control group only had scaling and root planning.The local symptoms,sulcus bleeding index(SBI),probing depth(PD) and attachment level(AL) of the two groups were observed in the second and fourth week after treatment.Results obtained from the two groups were compared.Results:There were significant differences in each clinical index between the experiment group and the control group(P
