Effects of VEGF and DEX on MMP-9 expression and motility of Tca-8113 cell
- VernacularTitle:VEGF、DEX对舌鳞癌细胞株MMP-9表达及侵袭力的影响
- Author:
Ying ZHANG
;
Yuanyuan KANG
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor;
Matrix metalloproteinase;
Tongue;
Squamous cell carcinom
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of indicated concentrations VEGF and DEX on MMP-9 expression and motility of Tca-8113 cell. Methods:Immunohistochemistry and RT-PCR methods were used to detect protein and mRNA changes of MMP-9 in tongue squamous cell with VEGF and DEX treatment. Cell motility was also observed with Transwell incubation.Results:The level of protein and mRNA of MMP-9 as well as cell motility increased with indicated concentrations VEGF(1,5,10 ng/ml) in a dose dependent way(P
