Study of a Bio-oss and rhBMP-2 composite repairing the alveolar bone defects around heterogenous implanted teeth
- VernacularTitle:Bio-oss/rhBMP-2复合体修复异种再植牙周围骨缺损的实验研究
- Author:
Zhifang CHEN
;
Maochang YE
;
Xiaohong DING
- Publication Type:Journal Article
- Keywords:
Bio-oss;
rhBMP-2;
Replantation tooth;
Osseointegration
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the reliability and effects of a compound bone substitute materials Bio-oss artificial bone grafts with recombinant human bone morphogenic protein-2(rhBMP-2) filling the alveolar bone defects around heterogenous replanted teeth. Methods:3 dogs′ bilateral mandible 3rd premolars(6 sites) were extracted. The defect sites without buccal and lingual alveolar bone were prepared for the heterogenous implanted teeth and the compound of Bio-oss and rhBMP-2 filled the alveolar bone defects around. The bone regeneration was observed by naked eye, radiograph, histology and histomorphometric analysis after 2, 3 months. Results:The new alveolar bone showed osteogenesis and calcification after 2 months, and intergrated with implanted teeth root under the light microscope and X ray. The new bone trabecular thickness(Tb.Th) augmented continuously. Differences of the bone area(B.Ar) and bone perimeter(B.Pm) were statistically significant after 2nd and 3rd month(P
