Study of drug distribution in tissue during treatment with targeting and continuous interstitial chemotherapy in the oral squamous cell carcinoma
- VernacularTitle:靶向持续性组织间化疗口腔癌局部组织及淋巴结内药物分布的初步研究
- Author:
Yunze XUAN
;
Lei ZHENG
;
Jianguo ZHANG
;
Jie ZHANG
;
Yan GAO
- Publication Type:Journal Article
- Keywords:
Interstitial chemotherapy;
Cisplatin;
Squamous cell carcinoma;
Lymph node
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the drug distribution in the local tissues and lymph nodes treated with targeting and continuous interstitial chemotherapy for the oral squamous cell carcinoma before operation. Methods:8 patients with oral squamous cell carcinoma were treated by implanting the sustain-released cisplatin around and into the primary lesion. Drug distribution in tissue were studied by the graphite furnace atomic absorption spectrometry. Results:The drug concentration in the center of the tumor,1 cm and 2 cm from the tumor fringe were (34.877 1?15.720 8),(20.690 0 ?15.688 6) and (6.635 7?3.862 3) ?g/g, respectively. The drug concentration within lymph nodes of the sub-mental and submandibular area, deep cervical lymph nodes for the upper,middle and lower were(2.991 4?3.055 7),(4.026 0 ?3.692 0), (7.192 0 ? 8.958 7) and (5.028 5?3.484 3)?g/g, respectively. Conclusion:Targeting and continuous interstitial chemotherapy for the oral squamous cell carcinoma by implanting sustain-released cisplatin can increase drug concentration in the local tissues and the lymph nodes, to attain good efficacy of targeting chemotherapy.
