Inhibitory effects of green-tea polyphenol on inflammatory agents in gingival epithelial cells
- VernacularTitle:绿茶多酚对牙龈上皮细胞内炎症因子的抑制作用
- Author:
Yurong KOU
;
Yaping PAN
- Publication Type:Journal Article
- Keywords:
Porphyromonas gingivalis;
Gingival epithelial cells;
Epigallocatechin gallate (EGCg);
Prostaglandin E2(PGE2);
Cyclooxygenase-2(COX-2);
Matrix metalloproteinase-3(MMP-3)
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of green-tea polyphenol, (epigallocatechin gallate,EGCg) on the cellular inflammatory responses of gingival epithelial cells. In order to find out a safe and efficient inflammation-inhibitor for periodontitis prevention and treatment. Methods:A model of cellular inflammatory responses of gingival epithelial cells stimulated by Porphyromonas gingivalis vesicles in vitro was established. The effects of EGCg on PGE2 production of gingival epithelial cells was detected by ELISA. Further more, the effects of EGCg on COX (cyclooxygenase)-2 and MMP (matrix metalloproteinase)-3 mRNA expression were determined by Real-time RT-PCR. Results:EGCg dose-dependently inhibited PGE2 production and COX-2, MMP-3 mRNA expressions. Conclusion:EGCg has inhibitory effects on cellular inflammatory responses of gingival epithelial cells and possesses the potentiality to be a periodontal inflammation-inhibitor.
