The correlation between interleukin-1 receptor antagonist genotype and chronic periodontitis with diabetes patients
- VernacularTitle:白细胞介素1受体拮抗剂基因型与糖尿患者群中牙周炎的关系
- Author:
Qing HUANG
;
Jinfu GAO
;
Yanan WANG
- Publication Type:Journal Article
- Keywords:
Periodontitis;
Diabetes mellitus(II);
Receptors;
Interleukin-1;
Genotype;
Disease;
Susceptibility
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation of interleukin-1 receptor antagonist ( IL-1ra) genotype and chronic periodontitis in diabetes patients. Methods: Genomic DNA was obtained from blood samples of 186 patients with diabetes, of which 108 patients with chronic periodontitis, another 78 patients without chronic periodontitis. Individuals A2 Genotypes of IL-1RN intron 2 VNTR was analyzed by SSP-PCR method. Then compared the differences in distribution of each genotype A2. Results:A significant over-representation of IL-1RN intron 2 VNTR allele A2 was found in chronic periodontitis of diabetes mellitus group(?2=3.579,P=0.040). Conclusion:IL-1RN intron 2 VNTR allele A2 may be a risk indicator for the susceptibility of chronic periodontitis in diabetes mellitus.
