The effect of simvastatin on bone formation during the retention after orthodontic tooth movement
- VernacularTitle:辛伐他汀对正畸牙齿保持阶段骨形成的影响
- Author:
Yuanping CHEN
;
Guanghong HAN
;
Yanhua JIANG
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Orthodontics;
Retention;
ALP;
BGP;
BMD
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of of simvastatin on bone formation and bone mineral density(BMD) during the retention after orthodontic tooth movement. Methods:Orthodontic tooth movement of upper first molar was performed in 40 rats with coil spring for 21 days. 40 rats were randomly allocated into 5 groups: basic control group,negative control group and 3 simvastatin groups(2.5 mg?kg-1, 5.0 mg?kg-1 and 10.0 mg?kg-1respectively).Rats in basic control group were killed when appliances were removed after 21 days.The experimental groups were administered simvastatin daily from 1 day before appliances removed for 4 weeks.The negative control group received the isotonic saline as control.4 weeks later all animals were anesthetized and killed. Level of serum Ca and P in blood, ALP, BGP and BMD were monitored.Results:①Between experimental groups and the negative control group, in amounts of ALP and BGP,the anterior were higher than the posterior (P0.05). ②The alveolar near the maxillary first molar,BMD of the basic control group was the highest(P
