A study on the preparation of biodegradable chitosan thermosensitive hydrogel for minocycline-HCl gelatin microspheres and its effects on experimental rats gingivitis
- VernacularTitle:盐酸米诺环素微球凝胶的制备及对大鼠实验性牙龈炎的抑制作用
- Author:
Rong WANG
;
Zhiwei MA
;
Xiaojuan WANG
- Publication Type:Journal Article
- Keywords:
Minocycline;
Gelatin microspheres;
Thermosensitive hydrogel;
Rats;
Gingivitis
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare a functional chitosan thermosensitive hydrogel for minocycline-HCl gelatin microspheres and observe its effects on repairing experimental rats gingivitis. Methods: Minocycline-HCl gelatin microspheres were prepared by using gelatin as core material and emulsion crosslinking method, then the latter was incorporated into the chitosan thermosensitive hydrogel. Established an experimental gingivitis model in SD rats and to observe the effect of hydrogel on gingivitis. Results: Microspheres thermosensitive hydrogel had obviously sustained effects on gingivitis. Results showed that GI,PD in experiment group were significantly improved. Conclusion: The chitosan thermosensitive hydrogel loading of minocycline-HCl gelatin microspheres have antiphlogistic effects on experimental rats gingivitis.
