Experimental study of cleft palate repair by rhBMP-2/Co/PLGA composite membrane
- VernacularTitle:rhBMP-2/Co/PLGA复合生物膜对腭裂骨缺损修复的实验研究
- Author:
Guangzhu JIN
;
Zhanxin WANG
;
Hongchen SUN
- Publication Type:Journal Article
- Keywords:
Guided bone regeneration;
Cleft palate;
Bone defect
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study whether the guided bone regeneration (GBR) technique can be used to achieve good bone formation in the defects of palate. Methods:Bone defect in the shape of triangle with the height of 4 cm and base line of 1.5 cm was created in the middle of palate in each of 16 adult dogs. The dogs were equally divided into experimental group(A) and control group(B). rhBMP-2/Co/ PLGA membrane was implanted in the defects in group A and the Co/ PLGA membrane in group B. The maxillary bone were observed by CT scan at 4, 8, 12 and 24 weeks after operation. The defect repair was observed by histological examination. Results:CT and histological examinations showed that new bone formation in group A was better than that in group B. 24 weeks after operation the defects in group A were completely repaired by new bone, those in group B partly repaired. Conclusion:The rhBMP-2/Co/PLGA composite membrane can be used to repair the defects in palate.
