Expression of MMP-1 and MMP-8 in periodontal tissues in rats with periodontitis
- VernacularTitle:MMP-1及MMP-8在大鼠牙周炎模型牙周组织中的表达与分布
- Author:
Shu MENG
;
Yu CHEN
;
Yafei WU
;
Xiaoqin ZHAO
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases;
Periodontitis;
Immunohistochemistry;
Animal model
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of MMP-1 and MMP-8 in periodontal tissues in rats with periodontitis at different stages of inflammation with varied severity. Methods:Periodontitis was induced by silk ligature. P.gingivalis(Pg) or Pg with F.nu were used to induce the varied severity of periodontitis in 40 rats. 14 and 28 days after periodontitis induction the animals were sacrificed, periodontal tissues were immunohistochemically stained by antibody of MMP-1 and MMP-8 respectively. Results:MMP-1 and MMP-8 were both strongly positive in gingival epithelia cells and fibroblasts in periodontal ligament in rats with periodontitis.Higher expression of MMP-1 and MMP-8 was observed at 14 d than at 28 d(P0.05). Conclusion:The expression of MMP-1 and MMP-8 varies in different stage of periodontitis. MMP-1 and MMP-8 may play an important role in development of periodontitis.
